Early Diagnosis and Preventive Therapy in Parkinsons Disease by Horst Przuntek (

Description: Early Diagnosis and Preventive Therapy in Parkinsons Disease by Horst Przuntek, Peter Riederer This work deals with early diagnosis and early preventive treatment of Parkinsons disease, which may sustain the process underlying the disease. By use of psychometric, kinesiologic, physiologic, histologic, biochemical, endocrinologic, pharmacologic and imaging techniques. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description At the time when "Parkinsons Disease" is diagnosed in a patient, roughly two-thirds of dopaminergic neurons of substantia nigra are already degenerated. The onset of the disease must, therefore, be much earlier. This work deals with early diagnosis and early preventive treatment which may sustain the process underlying the disease. By use of psychometric, kinesiologic, physiologic, histologic, biochemical, endocrinologic, pharmacologic and imaging techniques, including positron-emission tomography and brain mapping, specialists tried to focus on new diagnostic criteria. New methods including psychometric evaluation, apparative measurement of movement, analysis of peripheral blood and urinary constituents have supplemented this approach. It has been agreed that early preventive therapy consists of low dosis of L-DOPA, plus benserazide, L-deprenyl and dopaminergic agonists. Table of Contents The premorbid personality of patients with Parkinsons disease.- Parkinsons disease: development of dementia in aging.- Psychometric assessment of early signs of dementia in special consideration of Parkinsons and Alzheimers disease — an update.- Sensory and musculo-skeletal dysfunction in Parkinsons disease—premonitory and permanent.- Autonomic nervous system screening in patients with early Parkinsons disease.- Clinical and biochemical characteristics of early depression in Parkinsons disease.- Psychomotor investigations in depressed patients by comparison with Parkinson patients.- Quantitative analysis of voluntary and involuntary motor phenomena in Parkinsons disease.- Motor performance test.- Measuring body movements in neurological disease, with special reference to Parkinsons disease.- Long-term measurement of tremor: early diagnostic possibilities.- Tremor and electrically elicited long-latency reflexes in early stages of Parkinsons disease.- Evoked potentials in Parkinsons disease.- Brain mapping of EEG and evoked potentials during physiological aging and in Parkinsons disease, dementia and depression.- Positron emission tomography in Parkinsons disease glucose metabolism.- Parkinsons disease studied using PET.- Pathobiochemistry of the extrapyramidal system: a "short note" review.- Dopaminergic neurotransmission and status of brain iron.- Dopaminergic modulation of neuropeptide gene expression in the rat striatum.- The diagnostic relevance of Lewy bodies and other inclusions in Parkinsons disease.- Cytoskeletal pathology of the Lewy bodies.- Plasma concentrations of endogenous DOPA and 3-O-methyl-DOPA in rats administered benserazide and carbidopa alone or in combination with the reversible COMT inhibitorRo41-0960.- Catecholamines in urine, blood and cerebrospinal fluid.- 3H-spiperone binding to lymphocytes is increased in schizophrenic patients and decreased in parkinson patients.- Platelet MAO-B activity in humans and stumptail monkeys: in vivo effects of the reversible MAO-B inhibitor Ro19-6327.- Aspartate, glutamate, and glutamine in platelets of patients with Parkinsons disease.- Hypothalamic dysfunction and neuroendocrine research in Parkinsons disease.- The MPTP model: an update.- Histochemistry of MAO subtypes in the brainstem of humans: a relation to the radical hypothesis of Parkinsons disease?.- Importance of dopaminergic and GABAergic neurones of the nucleus accumbens and the caudate nucleus for motoricity.- Is D-1 receptor stimulation important for the anti-parkinson activity of dopamine agonists?.- Pharmacological and clinical-pharmacological aspects of D1- and D2-receptors.- Chemical modulation of membrane-bound receptors.- Transplantation of dopamine-synthesizing cells — new therapy for Parkinsons disease?.- L-dopa in Parkinsons disease.- Pharmacokinetic investigations of various levodopa formulations.- Iron therapy in Parkinsons disease. Stimulation of endogenous presynaptic L-DOPA biosynthesis by the iron compound oxyferriscorbone.- Provisional experiences with the combination of L-dopa and L-deprenyl.- Clinical pharmacology of amantadine and derivatives.- Dopamine agonist treatment in early Parkinsons disease.- Subcutaneous apomorphine in Parkinsons disease.- Continuous dopaminergic stimulation with parenteral lisuride in complicated Parkinsons disease.- Discussion. Promotional Springer Book Archives Long Description At the time when "Parkinsons Disease" is diagnosed in a patient, roughly two thirds of dopaminergic neurons of substantia nigra are already degenerated. The onset of the disease must, therefore, be much earlier. This book deals with early diagnosis and early preventive treatment which may sustain the process underlying the disease. By use of psychometric, kinesiologic, physiologic, histologic, biochemical, endocrinologic, pharmacologic and imaging techniques, including positron-emission tomography and brain mapping, specialists tried to focus on new diagnostic criteria. New methods including psychometric evaluation, apparative measurement of movement, analysis of peripheral blood and urinary constituents have supplemented this approach. It has been agreed that early preventive therapy consists of low dosis of L-DOPA plus benserazide, L-deprenyl and dopaminergic agonists. Details ISBN3211820809 Short Title EARLY DIAGNOSIS & PREVENTIVE T Series Key Topics in Brain Research Language English ISBN-10 3211820809 ISBN-13 9783211820803 Media Book Format Paperback Publisher Springer Verlag GmbH Imprint Springer Verlag GmbH Place of Publication Vienna Country of Publication Austria Edited by Peter Riederer Pages 447 Year 1988 Publication Date 1988-12-30 Illustrations XIV, 447 p. DOI 10.1007/978-3-7091-8994-8 Author Peter Riederer DEWEY 616.833 Audience Undergraduate We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96385762;

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