Autophagy and Cancer by Hong-Gang Wang (English) Hardcover Book

Description: Autophagy and Cancer by Hong-Gang Wang With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. Notes ¿¿Summarizes the key players that function in autophagosome formation, elongation and maturation¿ and its involvement in cancer progressionProvides latest research of how autophagy is regulatedExplores the roles of autophagy in tumorigenesis¿ Back Cover This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer. Author Biography Dr. Hong-Gang Wang is the Lois High Berstler Professor, Department of Pharmacology at Penn State College of Medicine. Dr. Wang is a leading research scientist in the area of autophagy and cancer. Table of Contents Preface.- Historical Overview of Autophagy.- The Core Molecular Machinery of Autophagosome Formation.- The origin of autophagosomes: The beginning of an end.- Signal Transduction Regulation of Autophagy.- Role of Autophagy in Tumorigenesis.- Selective autophagy and cancer.- Oncogenes and tumor suppressor genes in autophagy.- Autophagy and Immunity.- Autophagy and the Tumor Microenvironment.- Autophagy and Cancer Therapy.- The Crosstalk between Apoptosis & Autophagy.- Autophagy and Cancer Drug Discovery.- Index. Feature Summarizes the key players that function in autophagosome formation, elongation and maturation and its involvement in cancer progression Provides latest research of how autophagy is regulated Explores the roles of autophagy in tumorigenesis Details ISBN1461465605 Language English Year 2013 ISBN-10 1461465605 ISBN-13 9781461465607 Format Hardcover Short Title AUTOPHAGY & CANCER 2013/E Series Current Cancer Research Media Book Series Number 8 Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States Edited by Hong-Gang Wang Edition 2013th Illustrations XI, 261 p. DOI 10.1007/978-1-4614-6561-4 AU Release Date 2013-03-30 NZ Release Date 2013-03-30 US Release Date 2013-03-30 UK Release Date 2013-03-30 Author Hong-Gang Wang Pages 261 Publisher Springer-Verlag New York Inc. Edition Description 2013 ed. Publication Date 2013-03-30 Alternative 9781489991775 DEWEY 616.994071 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96313409;

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